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Article

A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle.

The Journal of cell biology - 12 Mar 2007

Rajendra T K, Gonsalvez Graydon B, Walker Michael P, Shpargel Karl B, Salz Helen K, Matera A Gregory

Abstract excerpt

Mutations in human survival motor neurons 1 (SMN1) cause spinal muscular atrophy (SMA) and are associated with defects in assembly of small nuclear ribonucleoproteins (snRNPs) in vitro. However, the etiological link between snRNPs and SMA is unclear. We have developed a Drosophila melanogaster system to model SMA in vivo. Larval-lethal Smn-null mutations show no detectable snRNP reduction, making it unlikely that...

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Source

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Identifiers

PMID: 17353360
DOI: 10.1083/jcb.200610053
PMCID: PMC2064057

Genes

SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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