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Interaction of PHGDH with IGF2BP1 facilitates m6A-dependent stabilization of TCF7L2 mRNA to confer multi-drug resistance in gastric cancer

2024-06-18

Abstract excerpt

<title>Abstract</title> <p>Background Multi-drug resistance (MDR) remains a significant barrier to effective chemotherapy and results in poor prognosis of gastric cancer (GC) patients. Exploring the mechanism of MDR is of great significance for identifying biomarkers of resistance and developing new treatment strategies. Methods The combination of multi-omics and bio-informatics analysis with experimental valid...

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Literature Corpus work
1f3b8acc-906a-54c3-a115-e0253fffbd02
DOI
10.21203/rs.3.rs-4507758/v1
Open publication

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Interaction of PHGDH with IGF2BP1 facilitates m6A-dependent stabilization of TCF7L2 mRNA to confer multi-drug resistance in gastric cancerDOI 10.21203/rs.3.rs-4507758/v1
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