Article

Site level factors that affect the rate of adaptive evolution in humans and chimpanzees; the effect of contracting population size

2021-06-06

Abstract excerpt

It has previously been shown in other species that the rate of adaptive evolution is higher at sites that are more exposed in a protein structure and lower between amino acid pairs that are more dissimilar. We have investigated whether these patterns are found in the divergence between humans and chimpanzees using an extension of the MacDonald-Kreitman test. We confirm previous findings and find that the rate of a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f34c5be-93a0-573b-aa41-9a796440b8a2
DOI: 10.1101/2021.05.28.446098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Site level factors that affect the rate of adaptive evolution in humans and chimpanzees; the effect of contracting population sizeDOI 10.1101/2021.05.28.446098Read

Changing Population Size in McDonald-Kreitman Style Analyses: Artifactual Correlations and Adaptive Evolution between Humans and Chimpanzees.Semantic proximity Read

Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice and Drosophila melanogaster.Semantic proximity Read

Factors that affect the rates of adaptive and non-adaptive evolution at the gene level in humans and chimpanzeesSemantic proximity Read

Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.Semantic proximity Read

Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared to mice and <i>Drosophila melanogaster</i>Semantic proximity Read

Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis.Semantic proximity Read

Adaptive Protein Evolution in Animals and the Effective Population Size HypothesisSemantic proximity Read

Nonadaptive processes in primate and human evolution.Semantic proximity Read

Changing effective population size and the McDonald-Kreitman test.Semantic proximity Read

Significance of population size on the fixation of nonsynonymous mutations in genes under varying levels of selection pressure.Semantic proximity Read

Should we expect substitution rate to depend on population size?Semantic proximity Read

The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.Semantic proximity Read