Should we expect substitution rate to depend on population size?

doi:10.1093/genetics/150.2.911

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Article

Should we expect substitution rate to depend on population size?

Genetics - 1 Oct 1998

Cherry J L

Abstract excerpt

The rate of nucleotide substitution is generally believed to be a decreasing function of effective population size, at least for nonsynonymous substitutions. This view was originally based on consideration of slightly deleterious mutations with a fixed distribution of selection coefficients. A re...

Topics

Amino Acid Substitution
Computer Simulation
Evolution, Molecular
Genetic Variation
Models, Genetic
Models, Statistical
Mutagenesis
Population Density
Proteins
Quantitative Trait, Heritable

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