Back to search

Article

Gamma-synuclein promotes Bevacizumab resistance by activating vascular endothelial growth factor receptor in colorectal cancer

2024-11-27

Abstract excerpt

<title>Abstract</title> <p>Resistance to Bevacizumab (Bev) is emerging as a major clinical problem. Gamma-synuclein (SNCG) is overexpressed in the tumor vasculature and various cancer cells. There are no studies on the role of SNCG in Bev resistance. Here, we analyzed the effect of SNCG on Bev resistance in vitro and in vivo, assessed the impact of combining an anti-SNCG monoclonal antibody (McAb, 42#) with Bev o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1f06a3fe-3971-5d7c-8610-445a227d9d81
DOI
10.21203/rs.3.rs-5414606/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Gamma-synuclein promotes Bevacizumab resistance by activating vascular endothelial growth factor receptor in colorectal cancerDOI 10.21203/rs.3.rs-5414606/v1
Synuclein-γ (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic diseaseSemantic proximity
γ‐Synuclein and the progression of cancerSemantic proximity
Loss of Epigenetic Control of <i>Synuclein-γ</i> Gene as a Molecular Indicator of Metastasis in a Wide Range of Human CancersSemantic proximity
Unconventional secretion of synuclein-γ promotes tumor cell invasion.Semantic proximity
Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance.Semantic proximity
BRAF-Mutated Colorectal Cancer: Clinical and Molecular Insights.Semantic proximity
Systematic analysis of potential targets of the curcumin analog pentagamavunon-1 (PGV-1) in overcoming resistance of glioblastoma cells to bevacizumabSemantic proximity
Loss of CD99L2 contributed to temozolomide resistance and glioblastoma tumorigenesis based on Genome-scale CRISPR/Cas9 screeningSemantic proximity
Select a neighboring publication to make it the new centre.