Article

Engineering a Single Extracellular Vesicle Protein and RNA Assay ( <sup>siEV</sup> PRA) via In Situ Fluorescence Microscopy in a UV Micropatterned Array

2022-08-06

Abstract excerpt

The physical and molecular heterogeneity of extracellular vesicles (EVs) confounds bulk biomarker characterization, thus encouraging the development of novel assays capable of profiling EVs at a single-vesicle resolution. Here, we present a single EV (siEV) protein and RNA assay ( siEV PRA) to simultaneously detect proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs) in siEVs. The siEV PRA consists of an arr...

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Literature Corpus work: 1ef13d6e-32b7-59f9-9a7c-5e6acfc148a0
DOI: 10.1101/2022.08.05.502995

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