Article

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

2021-08-10

Abstract excerpt

<h4>Objective</h4> GATA6 is a master regulator of pancreatic differentiation and a key regulator of the classical phenotype in pancreatic ductal adenocarcinoma (PDAC). Low GATA6 expression is associated with poor patient outcome. GATA4 is the second most expressed GATA factor in the pancreas. The aim was to assess whether, and how, GATA4 contributes to PDAC phenotype and to analyze the association of expression...

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Literature Corpus work: 1eee1993-482a-5d70-b1cc-bca89633cdde
DOI: 10.1101/2021.08.09.455642

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