Article

ABCC4 is a PGE2 Efflux Transporter in The Ovarian Follicle: A Mediator of Ovulation and A Potential Non-Hormonal Contraceptive Target

2021-02-16

Abstract excerpt

The role of Prostaglandins (PGs) in the ovulatory process is known. However, the role of the ATP binding cassette subfamily C member 4 (ABCC4), transmembrane PG carrier protein, in ovulation remains unknown. We report herein that ABCC4 expression is significantly upregulated in preovulatory human granulosa cells (GCs). We found that PGE2 efflux in cultured human GCs is mediated by ABCC4 thus regulating its extrace...

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Literature Corpus work: 1eb028a7-e81b-5da5-b34c-0573adff44fb
DOI: 10.21203/rs.3.rs-142822/v1

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