Article

Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma multiforme treatment resistance in females

2026-01-15

Abstract excerpt

<h4>Background</h4> Glioblastoma multiforme (GBM) is an aggressive brain tumor that is notoriously resistant to treatment, with an average survival time of 17 months. While the overall outcome is poor for both males and females, sex differences in GBM incidence and outcome suggest sex-specific biological mechanisms underlie tumorigenesis. In contrast, low-grade glioma (LGG) is a less aggressive brain tumor that t...

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Literature Corpus work: 1dda0225-c412-5bac-88ec-1fbf488bc4d8
DOI: 10.64898/2026.01.13.26344041

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