Article
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
BMC medicine - 7 Mar 2012
Bowerman Melissa, Murray Lyndsay M, Boyer Justin G, Anderson Carrie L, Kothary Rashmi
Abstract excerpt
BACKGROUND: Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (SMN1) gene and is typified by the loss of spinal cord motor neurons, muscular atrophy, and in severe cases, death. The SMN protein is ubiquit...
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