Article

Neutrophil Extracellular Traps Mediate <i>In Vitro</i> and <i>In Vivo</i> Degradation of α-Synuclein Amyloid Fibrils

2025-09-29

Abstract excerpt

Neutrophil extracellular traps (NETs) are chromatin-derived structures decorated with neutrophil enzymes such as elastase and myeloperoxidase. Our group has previously demonstrated that amyloid fibrils (AFs), regardless of their protein composition, induce NET release in vitro in human neutrophils through a process dependent on reactive oxygen species (ROS) generation by NADPH oxidase 2 (NOX-2). Moreover, the pro...

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Identifiers and source

Literature Corpus work: 967663bb-1635-5257-ad26-b47a986a7d40
DOI: 10.1101/2025.09.26.678871

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