Article

Development of Bootstrap-Weighted Oblique Random Forest Algorithm for Multiclass Drug-Induced Liver Injury Prediction and Risk Assessment in Humans

2026-06-15

Abstract excerpt

<title>Abstract</title> Drug-induced liver injury (DILI) accounts for more safety-related withdrawals of approved drugs than any other adverse event. Early detection of DILI potential is a central objective of preclinical safety assessment, and computational models are now routinely applied alongside experimental assays. We propose the Bootstrap-WeightedOblique Random Forest (BWORF), a tree ensemble that coupl...

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Literature Corpus work: 1d8a7183-f616-584e-877b-466e90eb8779
DOI: 10.21203/rs.3.rs-9918997/v1

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