Article

Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantation

2020-10-02

Abstract excerpt

At implantation, trophoblast derived from the trophectoderm of the blastocyst-stage embryo invades the endometrium to establish pregnancy. To understand how embryos breach the endometrial epithelium, we modelled human implantation using blastocysts or trophoblast stem cell spheroids cultured with endometrial epithelial cells (EEC). Blastocyst invasion of the EEC layer was initiated by multinuclear syncytiotrophobl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d6b0dc8-b554-5dce-ae86-195057e4eed3
DOI: 10.1101/2020.10.02.323659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantationDOI 10.1101/2020.10.02.323659Read

Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantationSemantic proximity Read

Epithelial-Mesenchymal Transition during Trophoblast DifferentiationSemantic proximity Read

Modeling embryo-endometrial interface recapitulating human embryo implantationSemantic proximity Read

Human endometrial cell-type-specific RNA sequencing provides new insights into the embryo–endometrium interplaySemantic proximity Read

Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation modelSemantic proximity Read

Single-Cell RNA Sequencing Reveals Regulatory Mechanism for Trophoblast Cell-Fate Divergence in Human Peri-Implantation EmbryoSemantic proximity Read

Stem cell models of human embryo implantation and trophoblast invasionSemantic proximity Read

Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptusesSemantic proximity Read

Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantationSemantic proximity Read

Dynamics of trophoblast differentiation in peri-implantation–stage human embryosSemantic proximity Read

Reconstructing the emergence of the human chorion via HIPPO-mediated trophoblast inductionSemantic proximity Read

Comparative Transcriptome Analysis of Human Trophectoderm and Embryonic Stem Cell-Derived Trophoblasts Reveal Key Participants in Early Implantation1Semantic proximity Read