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Article

Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives.

PLoS genetics - 1 Dec 2019

Caballero Madison, Seidman Daniel N, Qiao Ying, Sannerud Jens, Dyer Thomas D, Lehman Donna M, Curran Joanne E, Duggirala Ravindranath, Blangero John, Carmi Shai, Williams Amy L

Abstract excerpt

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a method for simulating relatives that can utilize either sex-specific or sex averaged genetic maps and also either a...

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PMID: 31860654
DOI: 10.1371/journal.pgen.1007979
PMCID: PMC6944377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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