Article

StrainFacts accurately quantifies both endogenous and live biotherapeutic product strain abundances in simulated and clinical vaginal microbiota samples

2025-08-21

Abstract excerpt

Live biotherapeutic products (LBPs) deliver microbial strains to modulate the host microbiota in order to promote health or treat and prevent disease. Since endogenous strains are already present, accurately evaluating LBP efficacy and mechanism of action requires distinguishing administered from endogenous strains. Although computational tools exist for inferring strains from short-read metagenomic data, few have...

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Literature Corpus work: 1cea86d7-47de-50cb-a854-d417da9f05d6
DOI: 10.1101/2025.08.15.670563

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