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Article

Human NF-κB1 Haploinsufficiency and Epstein–Barr Virus-Induced Disease—Molecular Mechanisms and Consequences

18 Jan 2018

Abstract excerpt

Nuclear factor kappa-light-chain enhancer of activated B cells 1 (NF-kB1)-related human primary immune deficiencies have initially been characterized as defining a subgroup of common variable immunodeficiencies (CVID), representing intrinsic B-cell disorders with antibody deficiency and recurrent infections of various kind. Recent evidence indicates that NF-kB1 haploinsufficiency underlies a variable type of...

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PMID: 29403474
DOI: 10.3389/fimmu.2017.01978

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