Inhibition of Ras1-MAPK pathways for hypha formation by novel drug candidates in <i>Candida albicans</i>

Abstract excerpt

The opportunistic human fungal pathogen Candida albicans has morphogenesis as a virulence factor. The morphogenesis of C. albicans is closely related to pathogenicity (1). Ras1 in C. albicans is an important switch in the MAPK pathway for morphogenesis (2, 3). The MAPK pathway is important for the virulence, such as cell growth, morphogenesis, and biofilm formation (4, 5). Ume6 is a well-known transcriptional fa...

Topics

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• Antifungal resistance and susceptibility
• Fungal and yeast genetics research
• Fungal Infections and Studies
• Herbal Medicine Research Studies
• Oral microbiology and periodontitis research
• Peptidase Inhibition and Analysis
• Plant-Microbe Interactions and Immunity
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

1c9c4054-a57f-5b9c-8224-ac5ccc071daf

DOI

10.1101/2021.07.06.451239