Article

Oral Administration of the Gut-bacterial Metabolite 5-hydroxyindole and Its Subsequent Acceleration of Gut Motility Have Marginal Effects on the Rat Microbiota

2022-02-23

Abstract excerpt

<h4>Background: </h4> Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology, including gut motility. We have previously shown that a wide variety of gut bacteria can produce 5-hydroxyindole from its precursor, dietary supplement and antidepressant, 5-hydroxytryptophan. When 5-hydroxyindole was administered orally in rats, it significantly accelerated the total g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c6fc140-32c2-5553-91df-abccadd4ec28
DOI: 10.21203/rs.3.rs-1374818/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oral Administration of the Gut-bacterial Metabolite 5-hydroxyindole and Its Subsequent Acceleration of Gut Motility Have Marginal Effects on the Rat MicrobiotaDOI 10.21203/rs.3.rs-1374818/v1Read

Tryptophan metabolism and the gut-brain axis: focus on specific gut microbial generaSemantic proximity Read

Indole, a Signaling Molecule Produced by the Gut Microbiota, Negatively Impacts Emotional Behaviors in RatsSemantic proximity Read

Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and DiseaseSemantic proximity Read

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanismsSemantic proximity Read

Gut microbiota-derived 5-hydroxyindole-3-acetic acid mediates the anti-colitis effect of Phellinus gilvus in miceSemantic proximity Read

Bacteria Engineered to Produce Serotonin Modulate Host Intestinal PhysiologySemantic proximity Read

Tryptophan Metabolites And Their Predicted Microbial Sources In Fecal Samples Of Healthy IndividualsSemantic proximity Read

Tryptophan and Its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain–Gut–Microbiome Axis: A Focus on Sex DifferencesSemantic proximity Read

Peripheral serotonin: cultivating companionship with gut microbiota in intestinal homeostasisSemantic proximity Read

Emerging Roles of Gut Serotonin in Regulation of Immune Response, Microbiota Composition and Intestinal InflammationSemantic proximity Read

Effects of continuous intravenous infusion of propofol on intestinal flora in ratsSemantic proximity Read

Biogenic Amines: Signals Between Commensal Microbiota and Gut PhysiologySemantic proximity Read