Article

Foxp1 controls neural stem cell competence and bias towards deep layer cortical fates

2018-08-07

Abstract excerpt

<h4>SUMMARY</h4> The laminar architecture of the mammalian neocortex depends on the orderly generation of distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. We identify critical roles for Foxp1 in maintaining RG identity and gating the temporal competency for early neurogenesis. High levels of Foxp1 are associated with early aRG and are required to promote proliferation and influence cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c3ea2cc-8067-5012-aaae-8ee4791704a1
DOI: 10.1101/386276

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Foxp1 controls neural stem cell competence and bias towards deep layer cortical fatesDOI 10.1101/386276Read

FOXP1 orchestrates neurogenesis in human cortical basal radial glial cellsSemantic proximity Read

Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neuronsSemantic proximity Read

Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine developmentSemantic proximity Read

Identity and Nature of Neural Stem Cells in the Adult Human Subventricular ZoneSemantic proximity Read

Unraveling Lineage Roadmaps and Cell Fate Determinants to Postnatal Neural Stem Cells and Ependymal cells in the Developing Ventricular ZoneSemantic proximity Read

Integrative single-cell transcriptomics clarifies adult neurogenesis and macroglia evolutionSemantic proximity Read

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate GyrusSemantic proximity Read

Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortexSemantic proximity Read

A cell fate decision map reveals abundant direct neurogenesis in the human developing neocortexSemantic proximity Read

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellumSemantic proximity Read

<i>FOXP</i> Genes Regulate Purkinje Cell Diversity in Cerebellar Development and EvolutionSemantic proximity Read

Dissecting Gene Regulatory Networks Governing Human Cortical Cell FateSemantic proximity Read