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Article

Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid

20 Mar 2020

Abstract excerpt

The activity and survival of retinal photoreceptors depend on support functions performed by the retinal pigment epithelium (RPE) and on oxygen and nutrients delivered by blood vessels in the underlying choroid. By combining single-cell and bulk RNA sequencing, we categorized mouse RPE/choroid cell types and characterized the tissue-specific transcriptomic features of choroidal endothelial cells. We found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32196081
DOI: 10.1084/jem.20190730

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