Article

XPRS: A Tool for Interpretable and Explainable Polygenic Risk Score

2024-10-24

Abstract excerpt

The polygenic risk score (PRS) is an important method for assessing genetic susceptibility to diseases; however, its clinical utility is limited by a lack of interpretability tools. To address this problem, we introduce eXplainable PRS (XPRS), an interpretation and visualization tool that decomposes PRSs into genes/regions and single nucleotide polymorphism (SNP) contribution scores via Shapley additive explanatio...

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Literature Corpus work: 1a22f78e-d3f5-519f-846e-722a81b5a1c0
DOI: 10.1101/2024.10.24.24316050

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