Article

DPPX-IgG-associated CNS hyperexcitability overlapping with acquired neuromyotonia (Isaacs syndrome): a case report

2026-08-06

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Dipeptidyl-peptidase-like protein-6 (DPPX/DPP6) autoimmunity is classically associated with central and enteric hyperexcitability, whereas acquired neuromyotonia (Isaacs syndrome) is a peripheral nerve hyperexcitability (PNH) disorder most often linked to CASPR2 but may be seronegative. Objective peripheral nerve abnormalities have only occasionally been doc...

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Literature Corpus work: 19c4a857-18a1-575a-81bc-d378d0d68c4e
DOI: 10.21203/rs.3.rs-10382775/v1

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