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The genetic risk factors, molecular pathways, microRNAs, and the gut microbiome in Alzheimer's disease.

Neuroscience - 21 Jun 2025

Aathira N S, Kaur Amanpreet, Kumar Arun, Dar Ghulam Mehdi, Nimisha, Sharma Abhay Kumar, Bera Pinki, Mahajan Bhawna, Chatterjee Atri, Saluja Sundeep Singh

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent form of dementia worldwide. It is a multifaceted condition resulting from interplay of genetic mutations (e.g., APP, PSEN1, PSEN2) that account for less than 5% of cases, several genetic risk variants such as APOE4, TREM2, CD33, CLU, SORL1, and CR1 contribute to disease susceptibility and epigenetic factors, which may mediate the influence of environmental and...

Topics

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Alzheimer Disease
Gastrointestinal Microbiome
CLU gene
SORL1 gene
TREM2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

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Identifiers

PMID: 40374065
DOI: 10.1016/j.neuroscience.2025.05.021

Genes

APP
CD33
CLU
CR1
PSEN1
PSEN2
SORL1
TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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