Article

Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia

2023-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Schizophrenia (SZ) is hypothesised to represent a costly trade-off in the evolution of the neurodevelopmental ontogenetic mechanisms associated with human-specific cognitive capacities. Human Accelerated Regions (HARs) are evolutionary conserved genomic regions that have accumulated human-specific sequence changes. These evolutionary markers function as neurodevelopmental transcription enhancers...

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Literature Corpus work: 18c4f526-1d69-5f4d-b836-daa437d48f20
DOI: 10.1101/2023.03.01.23286609

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