Article

Tubercidin Enhances Apoptosis in Serum-Starved and Hypoxic Mouse Cardiomyocytes by Inducing Nuclear Speckle Condensation

2024-12-01

Abstract excerpt

<title>Abstract</title> <p>Tubercidin, known for its antimicrobial, antiparasitic, and anticancer effects, faces clinical limitations due to adverse effects, especially cardiotoxicity risks for those with ischemic cardiomyopathy. This study aims to clarify the molecular pathways of Tubercidin-induced cardiotoxicity, focusing on nuclear speckles (NSs) disruption in cardiomyocytes under serum deprivation and/or hyp...

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Literature Corpus work: 189434c7-4bc1-54cc-bc81-daeaf4f1e293
DOI: 10.21203/rs.3.rs-5366953/v1

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