Article

Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny

2003-04-01

Abstract excerpt

Epidemiological studies from both iodine-sufficient and -deficient human populations strongly suggest that early maternal hypothyroxinemia (i.e., low circulating free thyroxine before onset of fetal thyroid function at midgestation) increases the risk of neurodevelopmental deficits of the fetus, whether or not the mother is clinically hypothyroid. Rat dams on a low iodine intake are hypothyroxinemic without being...

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Literature Corpus work: 17f9fce1-55ec-5043-ac7a-a2b66280aa06
DOI: 10.1172/jci200316262

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