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Maternal Hypothyroxinemia Impairs Spatial Learning and Synaptic Nature and Function in the Offspring

19 Jun 2008

Abstract excerpt

Neurological deficits in the offspring caused by human maternal hypothyroxinemia are thought to be irreversible. To understand the mechanism responsible for these neurological alterations, we induced maternal hypothyroxinemia in pregnant rats. Behavior and synapse function were evaluated in the offspring of thyroid hormone-deficient rats. Our data indicate that, when compared with controls, hypothyroxinemic...

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Identifiers

PMID: 18566112
DOI: 10.1210/en.2008-0560

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