Article

Polymeric nanoparticles delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne Muscular Dystrophy

2024-01-17

Abstract excerpt

Muscular dystrophies, such as Duchenne muscular dystrophy (DMD), are caused by permanent muscle injuries leading to chronic inflammation. In that context, macrophages harbor an altered inflammatory profile that contributes to fibrosis through the secretion of the profibrotic cytokine TGFβ1. We previously showed that AMP-activated protein kinase (AMPK) activation reduces TGFβ1 secretion by macrophages and improves...

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Literature Corpus work: 17e7dc01-3cbb-5097-a660-ddd242f13dc8
DOI: 10.1101/2024.01.16.575840

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Polymeric nanoparticles delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne Muscular DystrophyDOI 10.1101/2024.01.16.575840Read

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