Back to search

Article

Codon biased translation mediated by Queuosine tRNA modification is essential for the virulence of <i>Leishmania mexicana</i>

2025-06-30

Abstract excerpt

<h4>ABSTRACT</h4> The complex life cycle of the human parasite Leishmania mexicana requires rapid translational adaptation for survival in two distinct environments: the insect vector and the mammalian host. These protists lack conventional transcriptional control due to their unusual genome organization. Consequently, tRNA modifications may represent an additional mechanism for post-transcriptional regulation o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
17d6768e-8b59-5973-8661-f71d9b8e4ef8
DOI
10.1101/2025.06.30.662252
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Codon biased translation mediated by Queuosine tRNA modification is essential for the virulence of <i>Leishmania mexicana</i>DOI 10.1101/2025.06.30.662252
Queuosine modification of tRNA: its divergent role in cellular machinerySemantic proximity
Initiation codon context governs translation-coupled mRNA decay and coordinated expression in the human parasite <i>Leishmania</i>Semantic proximity
Growth-dependent tRNA Reprogramming and Codon Bias Link Translation to Metabolic State in <i>Enterococcus faecalis</i>Semantic proximity
Transfer RNA modification and infection – Implications for pathogenicity and host responsesSemantic proximity
Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma bruceiSemantic proximity
tRNA queuosine modification is involved in biofilm formation and virulence in bacteriaSemantic proximity
Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity
Transfer RNA (tRNA) Genes, Codon Usage and Translational Efficiency in <em>Leishmania infantum</em>Semantic proximity
Dynamic changes in tRNA modifications and abundance during T-cell activationSemantic proximity
Biosynthesis and function of posttranscriptional modifications of transfer RNAs.Semantic proximity
Comparison of codon usage bias across Leishmania and Trypanosomatids to understand mRNA secondary structure, relative protein abundance and pathway functions.Semantic proximity
Host tRNA modifications drive efficient translation of influenza A virus genome and impact host antiviral stress responsesSemantic proximity
Select a neighboring publication to make it the new centre.