Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early secreted antigenic target 6-kDa from Mycobacterium tuberculosis enhanced the protective innate immunity of macrophages partially via HIF1α.

Biochemical and biophysical research communications - 29 Jan 2020

Li Fake, Luo Jie, Xu Huan, Wang Yang, Jiang Wenbin, Chang Kai, Deng Shaoli, Chen Ming

Abstract excerpt

Early secreted antigenic target 6-kDa protein (ESAT6) is an essential virulence factor of Mycobacterium tuberculosis (MTb). However, ESAT6 helped fighting MTb infection according to vaccine studies. It's unclear whether ESAT6 confers protection via enhancing the innate immunity of macrophages, which are the first-line defense against MTb. We profiled the global transcriptional changes and characterized the innate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Monocytes

Share to Phagocytosis

Share to Reactive Oxygen Species

Share to RNA, Small Interfering

Share to THP-1 Cells

Source

Identifiers

PMID: 31735338
DOI: 10.1016/j.bbrc.2019.11.045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early secreted antigenic target 6-kDa from Mycobacterium tuberculosis enhanced the protective innate immunity of macrophages partially via HIF1α.PMID 31735338Read ↗

Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2Semantic proximity Read ↗

Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 PhenotypeSemantic proximity Read ↗

Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2Semantic proximity Read ↗

The role of ESAT-6 in tuberculosis immunopathologySemantic proximity Read ↗

ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosisSemantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

The Anti-Asthmatic Immune Mechanisms of <em>Mt.b </em>ESAT6-Fc Fusion Protein via Intranasal Immunization in Murine Allergic AsthmaSemantic proximity Read ↗

A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium–Host InteractionSemantic proximity Read ↗

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulenceSemantic proximity Read ↗

An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.Semantic proximity Read ↗

Immunological Characterization of Proteins Expressed by Genes Located in Mycobacterium tuberculosis-Specific Genomic Regions Encoding the ESAT6-like ProteinsSemantic proximity Read ↗

Identification and clinical validation of endoplasmic reticulum genes related to pulmonary tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.