Article

HDAC inhibitors modulate Hippo pathway signaling in hormone positive breast cancer

2024-10-15

Abstract excerpt

<title>Abstract</title> <p>Breast cancer has constantly been the leading causes of death in women, and hormone receptor (HR) positive, HER2 negative is the majority subtype. Histone deacetylase (HDAC) inhibitors have shown clinical benefit in HR (+) breast cancer patients. The hippo pathway proteins YAP/TAZ are often viewed as pro-tumorigenic, however, recent studies support a role of YAP as a tumor suppressor in...

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Literature Corpus work: 171cf1fa-aadb-55cc-9448-6f1eeddff8ba
DOI: 10.21203/rs.3.rs-4354853/v1

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