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Article

Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma

7 Nov 2019

Abstract excerpt

Previous studies from the Cancer Cell Line Encyclopedia (CCLE) project have adopted commercial pan-cancer cell line models to identify drug sensitivity biomarkers. However, drug sensitivity biomarkers in esophageal squamous cell carcinoma (ESCC) have not been widely explored. Here, eight patient-derived cell lines (PDCs) are successfully established from 123 patients with ESCC. The mutation profiling of PDCs can...

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PMID: 31700061
DOI: 10.1038/s41467-019-12846-7

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