Article

Actomyosin Contractility is a Potent Suppressor of Mesoderm Induction by Human Pluripotent Stem Cells

2024-10-01

Abstract excerpt

The activation of WNT signaling in human pluripotent stem cells (hPSCs) drives efficient conversion to lateral mesoderm, which can be further differentiated into cardiomyocytes. Stabilization of the WNT effector β-catenin promotes expression of mesoderm-specifying genes such as TBXT (which encodes Brachyury) and drives an epithelial-mesenchymal transition (EMT). Mechanical forces are essential for the self-organi...

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Literature Corpus work: 1695e530-ef7a-55e9-92d5-d9f263b7b1a7
DOI: 10.1101/2024.09.30.615859

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