Article

An isogenic cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

2020-10-12

Abstract excerpt

<title>Abstract</title> <p>Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in the fate-specification step has been reported, the mechanisms and key regulators underlying the accelerated proliferation of astrocyte precursor cells (APCs) in DS remain elusive. Here, we established an isogenic cell line panel, based on DS-specific induced...

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Literature Corpus work: 163fac39-8ab5-543e-ac19-e971e5cf4f90
DOI: 10.21203/rs.3.rs-79293/v1

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