Article

Applying Spatial Statistics to Spatial Transcriptomics Reveals Local Association Between M2-like Macrophages and Fibrosis in Diabetic Kidney Disease

2026-06-03

Abstract excerpt

<h4>Summary</h4> Renal fibrosis is the common final pathway of chronic kidney disease (CKD), driven in part by myofibroblast-mediated extracellular matrix deposition. M2 macrophages, hereafter referred to as MAC-M2, have been implicated in renal fibrosis, yet whether M2 macrophages are pro- or anti-fibrotic remains controversial, and the spatial context in which MAC-M2-fibrosis coupling occurs is unknown. Here, w...

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Literature Corpus work: 15935046-aaa0-55be-b87b-bc4ed45cd0c9
DOI: 10.64898/2026.05.31.729068

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