Article

Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold

2024-07-12

Abstract excerpt

The lipid phosphatase Fig4 modulates the production and turnover of the signaling lipid PI3,5P2 through participation in a complex with its opposing kinase, Fab1, and the scaffold protein Vac14. Fig4 point mutations are associated with neurological diseases for which there are currently no specific therapies. Pathology involving Fig4 is generally attributed to disruption of the Fab1-Vac14-Fig4 complex. Through gen...

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Literature Corpus work: 158d645c-dd32-5eea-8563-dea5b0623276
DOI: 10.1101/2024.07.12.603206

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Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffoldDOI 10.1101/2024.07.12.603206Read

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