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Article

Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.

Molecular biology of the cell - 1 Oct 2008

Botelho Roberto J, Efe Jem A, Teis David, Emr Scott D

Abstract excerpt

Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P(2)] regulates several vacuolar functions, including acidification, morphology, and membrane traffic. The lipid kinase Fab1 converts phosphatidylinositol-3-phosphate [PtdIns(3)P] to PtdIns(3,5)P(2). PtdIns(3,5)P(2) levels are controlled by the adaptor-like protein Vac14 and the Fig4 PtdIns(3,5)P(2)-specific 5-phosphatase. Interestingly, Vac14 and Fig4 serve a...

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Share to Flavoproteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Fluorescence

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Share to Phosphotransferases (Alcohol Group Acceptor)

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Source

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Identifiers

PMID: 18653468
DOI: 10.1091/mbc.e08-04-0405
PMCID: PMC2555960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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