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Article

Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.

Molecular biology of the cell - 1 Jan 2004

Rudge Simon A, Anderson Deborah M, Emr Scott D

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is synthesized by a single phosphatidylinositol 3-phosphate 5-kinase, Fab1. Cells deficient in PtdIns(3,5)P2 synthesis exhibit a grossly enlarged vacuole morphology, whereas increased levels of Pt...

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Identifiers

PMID: 14528018
DOI: 10.1091/mbc.e03-05-0297
PMCID: PMC307524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14528018-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.PMID 14528018Read ↗

Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.Semantic proximity Read ↗

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover.Semantic proximity Read ↗

Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.Semantic proximity Read ↗

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.Semantic proximity Read ↗

Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffoldSemantic proximity Read ↗

Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology.Semantic proximity Read ↗

Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.Semantic proximity Read ↗

Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.Semantic proximity Read ↗

Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.Semantic proximity Read ↗

FIG4 regulates lysosome membrane homeostasis independent of phosphatase function.Semantic proximity Read ↗

Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases.Semantic proximity Read ↗

Vid24p, a novel protein localized to the fructose-1, 6-bisphosphatase-containing vesicles, regulates targeting of fructose-1,6-bisphosphatase from the vesicles to the vacuole for degradation.Semantic proximity Read ↗

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