Article

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

2024-06-27

Abstract excerpt

Hormone therapy resistance and the ensuing aggressive progression of tumors present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy by hormone inhibition remain poorly understood. Here we show that Drosophila malignant epithelial tumors exhibit a comparable decrease in ecdysone signaling, the primary steroid hormone pathway in Drosophila . Furthermore, we fi...

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Literature Corpus work: 151ffbb8-ddfd-54cf-bc1a-c5f2771eab66
DOI: 10.1101/2024.06.27.600913

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