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Reconstructing the Transcriptional Regulatory Network of Probiotic <i>L. reuteri</i> is Enabled by Transcriptomics and Machine Learning

2023-07-03

Abstract excerpt

I Limosilactobacillus reuteri , a probiotic microbe instrumental to human health and sustainable food production, adapts to diverse environmental shifts via dynamic gene expression. We applied independent component analysis to 117 high-quality RNA-seq datasets to decode its transcriptional regulatory network (TRN), identifying 35 distinct signals that modulate specific gene sets. This study uncovers the fundamenta...

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Literature Corpus work
14d9f388-bc95-531a-b20a-81a9955f1a64
DOI
10.1101/2023.07.03.547516
Open publication

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Reconstructing the Transcriptional Regulatory Network of Probiotic <i>L. reuteri</i> is Enabled by Transcriptomics and Machine LearningDOI 10.1101/2023.07.03.547516
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