Article

Stochasticity explains differences in the number of <i>de novo</i> mutations between families

2020-09-20

Abstract excerpt

The number of de novo mutations (DNMs) in the human germline is correlated with parental age at conception, but this explains only part of the observed variation. We investigated whether there is a family-specific contribution to the number of DNMs in offspring. The analysis of DNMs in 111 dizygotic twin pairs did not identify a significant family-specific contribution. This result was corroborated by comparing DN...

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Literature Corpus work: 147f11fe-0f4d-5b04-9491-85b5897e828d
DOI: 10.1101/2020.09.18.303727

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