Article

Bioinformatic Characterization of Regulated IRE1a-Dependent Decay (RIDD) in Heart Failure

2026-08-20

Abstract excerpt

Inositol-requiring enzyme 1a (IRE1a) is a canonical signaling factor in the unfolded protein response (UPR). In addition to this essential role (which prevents the accumulation of misfolded proteins in the endoplasmic reticulum), the endoribonuclease activity of IRE1a targets multiple mRNAs for degradation through a process called Regulated IRE1a-Dependent Decay (RIDD). The products of over 50 genes have been iden...

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Literature Corpus work: 14742916-2a49-56da-9781-4dbd55d6667d
DOI: 10.64898/2026.08.20.745896

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