Back to search

Article

The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

2020-03-12

Abstract excerpt

Steroid compounds, which are expected to have dual functions in blocking host inflammation and MERS-CoV replication, were screened from a chemical library. Within this library, ciclesonide, an inhaled corticosteroid, suppressed human coronavirus replication in cultured cells, but did not suppress replication of respiratory syncytial virus or influenza virus. The effective concentration of ciclesonide to block SARS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7809bdd8-a33d-52fa-9387-60a31a3c7758
DOI
10.1101/2020.03.11.987016
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15DOI 10.1101/2020.03.11.987016
The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting viral replication-transcription complex in culture cellsSemantic proximity
Ciclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid proteinSemantic proximity
Inhibition of Human Coronaviruses by Piperidine-4-CarboxamidesSemantic proximity
Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung CellsSemantic proximity
N-chlorotaurine, a novel inhaled virucidal antiseptic is highly active against respiratory viruses including SARS-CoV-2 (COVID-19)Semantic proximity
Effect of Maraviroc and/or Favipiravir plus systemic steroids versus systemic steroids only on the viral load of adults with severe COVID-19: clinical trialSemantic proximity
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targetsSemantic proximity
Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19Semantic proximity
Select a neighboring publication to make it the new centre.