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Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

9 Aug 2023

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating glycolysis. We analyzed mitochondrial gene expression in nasopharyngeal and autopsy tissues from patients with coronavirus disease 2019 (COVID-19). In nasopharyngeal samples with declining viral titers, the virus blocked the...

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Share to Infectious Encephalopathies and Encephalitis
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PMID: 37556555
DOI: 10.1126/scitranslmed.abq1533

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