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Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal Pigs

2024-09-07

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> We aimed to investigate the relative efficacy of feeding different bile acids in preventing PNALD in neonatal pigs. <h4>METHODS</h4> Newborn pigs given total parenteral nutrition (TPN) combined with minimal enteral feeding of chenodeoxycholic acid (CDCA), or increasing doses of obeticholic acid (OCA) for 19 days. <h4>RESULTS</h4> Enteral OCA (5 and 15 mg/kg), but not CDCA (30 mg/kg) r...

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Literature Corpus work
12e5880c-7a86-555e-9f4b-9c71380cb27d
DOI
10.1101/2024.09.03.611073
Open publication

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Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal PigsDOI 10.1101/2024.09.03.611073
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