Article
Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations.
Physiological genomics - 1 May 2010
Barb C Richard, Hausman Gary J, Rekaya Romdhane, Lents Clay A, Lkhagvadorj Sender, Qu L, Cai W, Couture Oliver P, Anderson Lloyd L, Dekkers Jack C M, Tuggle Christopher K
Abstract excerpt
Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of melanocortin-4 receptor (MC4R) agonist [Nle(4), d-Phe(7)]-α-melanocyte stimulating hormone (NDP-MSH) in pigs homozygous for the missense mutation in the MC4R, D298 allele (n = 12), N298 allele (n = 12), or heterozygous (n = 12). Food intake (FI) was measured at 12 and 24 h after treatment. All...
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