Article

ClinAgent: A Five-Layer Architecture for Autonomous Clinical Trial Statistical Programming

2026-01-16

Abstract excerpt

Clinical trial statistical programming requires 12-24 FTE-months for a typical Phase 3 study, producing 100-500 tables, listings, and figures (TLFs) across 8-15 ADaM domains. Modern AI coding agents (Augment Code, Claude Code, Cline, Cursor) demonstrate remarkable reasoning capabilities but lack the domain-specific tools needed for clinical programming: they cannot read SAS datasets, parse ADaM specifications, ana...

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Literature Corpus work: 15854f5e-96ab-5a76-ad66-5017aa7614a4
DOI: 10.64898/2026.01.09.26343542

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