Article

TrialCode Agent: LLM-Assisted Clinical Code-Set Construction for Trial Emulation

2026-08-23

Abstract excerpt

<h4>Objective: </h4> Translating free-text clinical trial criteria into computable code sets is a valuable standardization practice that is necessary for producing reproducible real-world evidence studies but requires standardized interpretation across multiple clinical vocabularies. Methods We developed TrialCode Agent, a hybrid-large language model (LLM)-terminology verification agent that generates, formats, ve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82c52ad1-de6b-573f-a600-7d44a0b48ada
DOI: 10.64898/2026.08.20.26360962

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TrialCode Agent: LLM-Assisted Clinical Code-Set Construction for Trial EmulationDOI 10.64898/2026.08.20.26360962Read

LLM-Driven Target Trial Emulation with Human-in-the-Loop Validation for Randomized Trial: Automated Protocol Extraction and Real-World Outcome Evaluation <sup>Ψ</sup>Semantic proximity Read

Towards understanding the disease landscape of clinical trials in Germany: Ontology and embedding-based pipelines versus Large Language Models for ICD-10 HarmonizationSemantic proximity Read

Developing an open-source framework for LLM evaluation of patients using EHR clinical documentation; performance of LLMs relative to medical professionalsSemantic proximity Read

Inductive reasoning with large language models: a simulated randomized controlled trial for epilepsySemantic proximity Read

Large language models and retrieval augmented generation for complex clinical codelists: evaluating performance and assessing failure modesSemantic proximity Read

Implementation of Human-in-the-Loop ChatGPT-based Patient Screening Across Multiple Diverse Clinical TrialsSemantic proximity Read

Retrieval-Augmented Large Language Models for Clinically Aligned Adverse Event Coding in Acute Myeloid Leukemia Clinical TrialsSemantic proximity Read

An Automation Framework for Clinical Codelist Development Validated with UK Data from Patients with Multiple Long-term ConditionsSemantic proximity Read

CodeMergeR: A shiny-based application for codelist integrationSemantic proximity Read

A Proof-of-Concept Large Language Model Application to Support Clinical Trial Screening in Surgical OncologySemantic proximity Read

Evaluation of Care Quality for Atrial Fibrillation Across Non-Interoperable Electronic Health Record Data using a Retrieval-Augmented Generation-enabled Large Language ModelSemantic proximity Read

Evaluating Eight Retrieval-Augmented Generation (RAG) Large Language Models’ Responses to Clinical Questions: A Comparative StudySemantic proximity Read