Article

Lung Clearance Index as a definitive surrogate endpoint for therapeutic interventions in cystic fibrosis

2018-01-01

Abstract excerpt

Lung Clearance Index (LCI), a measure of ventilation inhomogeneity, reflects disease in distal airways predominantly affected in cystic fibrosis (CF). I hypothesised that improved understanding of LCI's clinimetric properties could support its progression to an accepted outcome measure. I aimed to define and explain differences between techniques and assess responsiveness to interventions. LCI is derived from mult...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10d4af5a-8bac-5c7c-8c00-8ed9fbd1627a
DOI: 10.25560/68542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lung Clearance Index as a definitive surrogate endpoint for therapeutic interventions in cystic fibrosisDOI 10.25560/68542Read

Airway clearance and exercise for people with cystic fibrosis: Balancing longevity with life.Semantic proximity Read

Improvement in Lung Clearance Index and Chest Computed Tomography Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older - The RECOVER Trial.Semantic proximity Read

Lung clearance index for monitoring early lung disease in alpha-1-antitrypsin deficiency.Semantic proximity Read

Outcome measures for cystic fibrosis gene therapy clinical trialsSemantic proximity Read

Lung clearance index response in patients with CF with class III CFTR mutations.Semantic proximity Read

Lung clearance index to characterize clinical phenotypes of children and adolescents with cystic fibrosis.Semantic proximity Read

Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis.Semantic proximity Read

Patient and caregiver perceptions of airway clearance methods used for cystic fibrosisSemantic proximity Read

Changes in LCI in F508del/F508del patients treated with lumacaftor/ivacaftor: Results from the prospect study.Semantic proximity Read

Long-term gas exchange characteristics as markers of deterioration in patients with cystic fibrosis.Semantic proximity Read

Measuring lung function in mice: the phenotyping uncertainty principle.Semantic proximity Read

Endogenous nitric oxide production in airways of patients with cystic fibrosisSemantic proximity Read