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Article

Lung clearance index to characterize clinical phenotypes of children and adolescents with cystic fibrosis.

BMC pulmonary medicine - 1 Apr 2022

Gambazza Simone, Ambrogi Federico, Carta Federica, Moroni Laura, Russo Maria, Brivio Anna, Colombo Carla

Abstract excerpt

BACKGROUND: Lung clearance index (LCI) is accepted as an early marker of lung disease in cystic fibrosis (CF), however the utility of LCI to identify subgroups of CF disease in the paediatric age group has never been explored. The aim of the study was to characterize phenotypes of children with CF using LCI as a marker of ventilation inhomogeneity and to investigate whether these phenotypes distinguished patients...

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Identifiers

PMID: 35365111
DOI: 10.1186/s12890-022-01903-5
PMCID: PMC8976307

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